Stem cells are special human cells that have the natural ability to generate new cell types. These have the potential to develop into many different cell types with specialized functions in the body. When these stem cells which can also be considered as raw materials, are given the right conditions, these divide to form daughter cells. These daughter cells formed become specialized cells (with specific functions) like muscle cells, bone cells, blood cells, or brain cells. That is why stem cells are considered the core of regenerative medicine as these can be manipulated to grow into any kind of cells that we want.
2. What is the procedure for stem cell harvesting?
The procedure of stem cell harvesting differs on the basis of the source from where it will be extracted. For example, if it is to be harvested from blood, then blood is drawn from a patient’s arm and it is processed to prepare stem cells.
3.Where is it harvested from?
There are various sources of stem cells from where it can be extracted – bone marrow, blood, and fat. We do the treatments with autologous stem cells i.e. patients own cells that are extracted from either of three sources.
4. Are there risks to harvesting?
There are no risks/ minimal risk to harvesting in general and depending on the procedure of drawing blood either from vein, or from bone marrow or isolating fat from the body, appropriate preventive measures are taken.
5. How long does the harvested quantity recover?
We harvest stem cells from patient’s own bone marrow or blood. Bone marrow is the site where formation of blood occurs and it is a continuous process. Just as in case of blood donation, a person need not worry about recovering the lost blood, the scenario is quite similar here. If 20 to 40 cc blood is harvested from the patient, it will be` recovered in a few days and would cause no harm.
6. Does the patient need prior training?
The patient need not necessarily have a prior knowledge as the counselling team informs the patient of every detail of the procedure, the expected outcomes, and the time of recovery. The team walks the patients through the whole process and the procedure is started only when the patient is well-informed and based on his/her consent.
7. What happens to the harvested cells?
The harvested cells are processed in the laboratory and concentrated preparation of harvested material is prepared. This concentrate is a mix of stem cells, growth factors, and biomolecules which help in regenerating tissue naturally, thereby healing wounds, and regaining the function of the body part where this concentrate is injected.
8. How are they used?
These are injected into the targeted area based on the treatment that is sought by the patients. Upon injection, the body initiates the wound healing process, which ultimately results in the growth of new cells around the injected site.
9. How are stem cells integrated into the ovary and what are the risks?
Harvested stem cells are injected into the ovary through a laparoscopic procedure where a needle is inserted into the ovary and multiple punctures are made. While these punctures are made, the stem cell concentrate is inserted into the ovary which would result in regaining the function of ovaries, thereby completing the process of ovulation and in most cases resulting in pregnancy. It is a minimally invasive, and an outpatient procedure and requires the use of anaesthesia.
General risks that may be associated with this minor surgery which includes accidental injury to internal organs or major blood vessels from the laparoscope or surgical instruments. Patients may experience mild to moderate pain post procedure in the abdomen. Mild problems may be caused by anaesthesia and also there is a rare chance of adhesions or scarring inside the body.
10. Is there an ideal candidate?
Any woman of biologically appropriate age willing to get pregnant and have not found success with other assisted reproductive technologies is an ideal candidate. This process has been successful in women with early menopause, and with other indications leading to infertility including asherman syndrome, premature ovarian failure, or primary ovarian insufficiency.
11. What do we expect from this procedure?
The expected outcome of this procedure is that ovary starts to function properly, the process of ovulation is restored, and the egg is released naturally in the uterus ready to be fertilized by a sperm, leading to pregnancy. However, it is not certain that the woman will be able to conceive naturally after this procedure. In many cases, assisted reproductive technologies are required to help the patient achieve successful pregnancy post this treatment.
12. When is this procedure necessary?
If you are someone who has not been able to conceive naturally or has had many failed attempts with assisted reproductive technologies, this procedure brings you a ray of hope to give it another try. The outcome would however, totally depends on individual’s biological response and will vary from individual to individual.
13. At what time of pathologies could this procedure be beneficial?
If a woman has been diagnosed with thin endometrium, poor ovarian reserve, intrauterine adhesions, early menopause, premature ovarian failure, or not being able to conceive through natural aids, this procedure can be beneficial.
14. What are you planning to do next in the field of regenerative medicine and infertility?
Due to the increase number of patients with premature ovarian failure we are enthusiastic to launch The International Centre Of Excellence For Regenerative Medicine in Infertility. Our aim is to help couples facing challenges to conceive due to:
– early onset of menopause
– low AMH Level
– Premature Ovarian Failure
– Primary Ovarian Insufficiency
– Thin Endometrial Lining
– Recurrent Implantation Failure
– Asherman Syndrome
– Low Sperm Count and Sexual Dysfunction
We have 15+ Years of Research in Stem Cell and Infertility and have worked to achieve the best protocol, most successful and safe. We have PhD and master degrees in this field, and have treated over 600 patients who had the criteria to be referred to donated oocytes. We have been able to acheive 58% Success Rate in these types of patients after using our Stem Cell Protocol (over 350 healthy babies were born worldwide!). We have published more than 30 papers in international journal. Recently, we have authored a book “Stemcell and Regenerative Medicine in Infertility” , the first and only book with this topic.
– International publications refer to us as “global leader in Regenerative & functional Reproductive medicine”.
– We are internationally recognised, doctors from all over the world have already chosen our program of training and fellowship in Stem Cell and Regenerative Medicine
– We have global presence, currently we have our centre in India, Romania, Jordan, Philippines and have collaborators in USA, Turkey, Lithuania, Iran, Muscat, Bahrain, KSA, Poland, UAE, Egypt, Morocco, France , Switzerland, Indonesia, and the list is increasing.
WHAT WE PLAN TO DO ?
– Go worldwide to the countries with interested patients for Stem Cell treatment for infertility
– Help and Treat patients worldwide
– Train doctors worldwide